Research in NZ
Professor Warren Tate, MSc, PhD & colleagues - University of Otago, Dunedin.
Professor Tate is an internationally respected biochemist, winner of the 2010 Rutherford Medal, the 2018 Marsden Medal, and was also named a Companion of the New Zealand Order of Merit in 2011.
Professor Tate's "research into how proteins are synthesised in living cells has revolutionised understanding in this area. His research has shown how proteins contribute to memory formation and neurological disease, and have important implications for HIV, Alzheimer's and chronic fatigue syndrome."
Professor Tate's research group has published two papers in recent months:
- A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS
Angus Mackay, Warren P Tate in International Journal of Immunopathology and Pharmacology (Dec 2018) https://doi.org/10.1177/2058738418812342
- Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome
Eiren Sweetman, Margaret Ryan, Christina Edgar, Angus MacKay, Rosamund Vallings, Warren Tate in International Journal of Immunopathology and Pharmacology (Jan 2019) https://doi.org/10.1177/2058738418820402
Prof Tate and his laboratory programme for 2019 would appreciate your donations to help fund further research. This is what they are looking into:
(A) Energy production
"We are determining in ME/CFS patients and age/gender matched healthy controls the complete bioenergetic profiles of the cell’s energy powerhouse (mitochondrion) and its effectiveness to produce energy. We will also investigate the levels of an important component of this energy production, CoQ10, in plasma and immune cells and whether the status of this biomolecule can be improved by the freely available supplement MitoQ."
(B) Epigenetic code dynamics
Studies have indicated that "the expression of many gene encoding products of biochemical pathways are ... functioning at lower level than normal". The aim is "to deduce which individual genes are affected, and how that translates into lower efficiency of biochemical pathways that might be sustaining ME/CFS".
Look here for a Dunedin newspaper article about Prof Tate from May 2018.
Dr Lynette Hodges, PhD & colleagues, Massey University, Palmerston North.
Hodges, LD., Nielsen, T., & Baken, D. (2018). Physiological measures in participants with chronic fatigue syndrome, multiple sclerosis and healthy controls following repeated exercise: a pilot study. Clinical Physiology and Functional Imaging. 38(4), 639-644. Read the article here.
Current research she is undertaking in 2019: The effects of exercise at anaerobic threshold on post exertional malaise in individuals with ME/CFS.
Dr Carolyn Wilshire, BSc, PhD, Victoria University, Wellington.
Critique and reanalysis of the PACE Trial
Wilshire, C. E., Kindlon, T., Courtney, R., Matthees, A., Tuller, D., Geraghty, K., & Levin, B. (2018). Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT. BMC psychology, 6(1), 6. Read the article here
Dr Don Baken, PhD and colleagues, Massey University